Skeletal and cardiac muscle excitation–contraction coupling commences with Nav1. 4/Nav1.
5-mediated, surface and transverse (T-) tubular, action potential generation. This initiates …

Quinoline-related antimalarial drugs have been associated with cardiotoxicity risk, in
particular QT prolongation and QRS complex widening. In collaboration with Medicines for …

Enterococci are important pathogens of nosocomial infections and are increasingly difficult
to treat due to their intrinsic and acquired resistance to a range of antibiotics. Therefore …

Cenobamate is a novel third-generation antiepileptic drug used for the treatment of focal
onset seizures and particularly for multi-drug-resistant epilepsy; it acts on multiple targets …

Due to the outbreak of the SARS-CoV-2 virus, drug repurposing and Emergency Use
Authorization have been proposed to treat the coronavirus disease 2019 (COVID-19) during …

The emergence of bacterial drug resistance poses a severe threat to global public health. In
particular, antimicrobial-resistant pathogens lead to a high rate of treatment failure and …

In recent years, computational cardiac electrophysiology simulations using mathematical
models have begun to be used in industrial and regulatory assessment of the proarrhythmic …

Cenobamate is a new and highly effective antiseizure compound used for the treatment of
adults with focal onset seizures and particularly for epilepsy resistant to other antiepileptic …

In the early phases of the COVID-19 pandemic, drug repurposing was widely used to identify
compounds that could improve the prognosis of symptomatic patients infected by SARS-CoV …

Cellular asymmetry is an important element of efficiency in the compartmentalization of
intracellular chemical reactions that ensure efficient tissue function. Improving the current 3D …