[HTML][HTML] Current strategies in design and synthesis of antifungals hybrid and chimeric diazine derivatives

D Diaconu, M Savu, C Ciobanu, V Mangalagiu… - Bioorganic & Medicinal …, 2025 - Elsevier
In the last decades fungal infections became a major threat to human health having an
unacceptably occurrence, a high rate of mortality and the number of patients at risk for these …

Revisiting methotrexate and phototrexate Zinc15 library-based derivatives using deep learning in-silico drug design approach

F Siddique, A Anwaar, M Bashir, S Nadeem… - Frontiers in …, 2024 - frontiersin.org
Introduction: Cancer is the second most prevalent cause of mortality in the world, despite the
availability of several medications for cancer treatment. Therefore, the cancer research …

Microwave-assisted synthesis, characterization, and molecular docking studies of new chlorophthalazine derivatives as anticancer activity

SA Abubshait, RJ Almalih, HA Abubshait… - Arab Journal of Basic …, 2024 - Taylor & Francis
A series of phthalazine derivatives have been synthesized using green protocol methods
under microwave irradiation. This involved subjecting chlorophthalazine to microwave …

2-Methyl-6-(4-aminophenyl)-4,5-dihydro-3(2H)-pyridazinone Synthon for Some New Annelated 1,2,3-Selena/Thiadiazoles and 2H-Diazaphospholes with …

IE El-Shamy, E Hleli, MA El-Hashash, I Kelnar… - Molecules, 2023 - mdpi.com
A convenient and efficient synthetic protocol for the new selenadiazole. Thiadiazole and
diazaphosphole derivatives incorporating a pyridazine moiety originating from 4-(4 …