A decade ago, we hypothesized that drug addiction can be viewed as a transition from
voluntary, recreational drug use to compulsive drug-seeking habits, neurally underpinned by …

This review discusses the evidence for the hypothesis that the development of drug
addiction can be understood in terms of interactions between Pavlovian and instrumental …

Addiction is a chronic, relapsing disorder, characterised by the long-term propensity of
addicted individuals to relapse. A major factor that obstructs the attainment of abstinence is …

Retrieving a memory can modify its influence on subsequent behavior. We develop a
computational theory of memory modification, according to which modification of a memory …

Over the past several years, drug addiction has increasingly been accepted to be a disease
of the brain as opposed to simply being due to a lack of willpower or personality flaw …

Memory consolidation refers to a slow process that stabilises a memory trace after initial
acquisition of novel events. The consolidation theory posits that once a memory is stored in …

Memory allows organisms to predict future events based on prior experiences. This requires
encoded information to persist once important predictors are extracted, while also being …

A growing body of evidence indicates that repeated exposure to cocaine leads to profound
changes in glutamate transmission in limbic nuclei, particularly the nucleus accumbens. This …

The capacity to remember our past experiences and organize our future draws on a number
of cognitive processes that allow our brain to form and store neural representations that can …

Finding effective long-lasting treatments for drug addiction has been an elusive goal.
Consequently, researchers are beginning to investigate novel treatment strategies including …