Impact of oxidized low density lipoprotein on vascular cells

J Galle, T Hansen-Hagge, C Wanner, S Seibold - Atherosclerosis, 2006 - Elsevier
Oxidized LDL (OxLDL) is a proatherogenic lipoprotein, accumulating in the vascular wall
and contributing to the pathogenesis of vascular dysfunction early in the development of …

Dual signaling evoked by oxidized LDLs in vascular cells

A Nègre-Salvayre, N Augé, C Camaré… - Free Radical Biology …, 2017 - Elsevier
The oxidative theory of atherosclerosis relies on the modification of low density lipoproteins
(LDLs) in the vascular wall by reactive oxygen species. Modified LDLs, such as oxidized …

The human paraoxonase gene cluster as a target in the treatment of atherosclerosis

ZG She, HZ Chen, Y Yan, H Li, DP Liu - Antioxidants & redox …, 2012 - liebertpub.com
The paraoxonase (PON) gene cluster contains three adjacent gene members, PON1, PON2,
and PON3. Originating from the same fungus lactonase precursor, all of the three PON …

Deciphering the mechanistic impact of acupuncture on the neurovascular unit in acute ischemic stroke: insights from basic research in a narrative review

H Jiang, C Zhang, M Lin, Y Yin, S Deng, W Liu… - Ageing Research …, 2024 - Elsevier
Ischemic stroke (IS), a severe acute cerebrovascular disease, not only imposes a heavy
economic burden on society but also presents numerous challenges in treatment. During the …

Oxidized low-density lipoproteins upregulate proline oxidase to initiate ROS-dependent autophagy

O Zabirnyk, W Liu, S Khalil, A Sharma… - …, 2010 - academic.oup.com
Epidemiological studies showed that high levels of oxidized low-density lipoproteins
(oxLDLs) are associated with increased cancer risk. We examined the direct effect of …

[HTML][HTML] Resveratrol protects against oxidized LDL-induced breakage of the blood-brain barrier by lessening disruption of tight junctions and apoptotic insults to …

YL Lin, HC Chang, TL Chen, JH Chang, WT Chiu… - The Journal of …, 2010 - Elsevier
Cerebrovascular endothelial cells (CEC) comprise the blood-brain barrier (BBB). In a
previous study, we showed that oxidized LDL (oxLDL) can induce apoptosis of mouse CEC …

Resveratrol attenuates oxidized LDL-evoked Lox-1 signaling and consequently protects against apoptotic insults to cerebrovascular endothelial cells

HC Chang, TG Chen, YT Tai, TL Chen… - Journal of Cerebral …, 2011 - journals.sagepub.com
Cerebrovascular endothelial cells (CECs) are crucial components of the blood—brain
barrier. Our previous study showed that oxidized low-density lipoprotein (oxLDL) induces …

Molecular signatures determining coronary artery and saphenous vein smooth muscle cell phenotypes: distinct responses to stimuli

DXF Deng, JM Spin, A Tsalenko, A Vailaya… - … and Vascular Biology, 2006 - Am Heart Assoc
Objective—Phenotypic differences between vascular smooth muscle cell (VSMC) subtypes
lead to diverse pathological processes including atherosclerosis, postangioplasty restenosis …

The periodontal pathogen Porphyromonas gingivalis cleaves apoB‐100 and increases the expression of apoM in LDL in whole blood leading to cell proliferation

T Bengtsson, H Karlsson, P Gunnarsson… - Journal of internal …, 2008 - Wiley Online Library
Objective. Several studies support an association between periodontal disease and
atherosclerosis with a crucial role for the pathogen Porphyromonas gingivalis. This study …

Oxidized phospholipids induce ceramide accumulation in RAW 264.7 macrophages: role of ceramide synthases

LM Halasiddappa, H Koefeler, AH Futerman… - PLoS …, 2013 - journals.plos.org
Oxidized phospholipids (OxPLs), including 1-palmitoyl-2-glutaroyl-sn-glycero-3-
phosphocholine (PGPC) and 1-palmitoyl-2-oxovaleroyl-sn-glycero-3-phosphocholine …