The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …

The past 10 years have seen great advances in our ability to manipulate cell fate, including
the induction of pluripotency in vitro to generate induced pluripotent stem cells (iPSCs). This …

Following immune attack, solid tumors upregulate coinhibitory ligands that bind to inhibitory
receptors on T cells. This adaptive resistance compromises the efficacy of chimeric antigen …

DNA methylation is a key epigenetic modification involved in regulating gene expression
and maintaining genomic integrity. Here we inactivated all three catalytically active DNA …

Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) resets their identity
back to an embryonic age and, thus, presents a significant hurdle for modeling late-onset …

Memories can be unreliable. We created a false memory in mice by optogenetically
manipulating memory engram–bearing cells in the hippocampus. Dentate gyrus (DG) or …

Clinical application of induced pluripotent stem cells (iPSCs) is limited by the low efficiency
of iPSC derivation and the fact that most protocols modify the genome to effect cellular …

The direct lineage reprogramming of one specialized cell type into another using defined
factors has fundamentally re-shaped traditional concepts regarding the epigenetic stability of …

Human pluripotent stem cells are a powerful tool for modeling brain development and
disease. The human cortex is composed of two major neuronal populations: projection …

Considerable progress has been made in identifying signaling pathways that direct the
differentiation of human pluripotent stem cells (hPSCs) into specialized cell types, including …