Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Phospholipids play multiple roles in cells by establishing the permeability barrier for cells
and cell organelles, by providing the matrix for the assembly and function of a wide variety of …

Mechanosensory transduction underlies a wide range of senses, including proprioception,
touch, balance, and hearing. The pivotal element of these senses is a mechanically gated …

The transient receptor potential (TRP) protein superfamily consists of a diverse group of
Ca2+ permeable nonselective cation channels that bear structural similarities to Drosophila …

A basic feature of eukaryotic cells is that they contain a nucleus and numerous distinctive
membrane-bounded organelles within the cytoplasm. Prominent among these intracellular …

Apoptosis has been identified recently as a component of many cardiac pathologies.
However, the potential triggers of programmed cell death in the heart and the involvement of …

This review focuses on two phospholipase activities involved in eukaryotic signal
transduction. The action of the phosphatidylinositol-specific phospholipase C enzymes …

Drosophila visual transduction is the fastest known G-protein-coupled signaling cascade
and has therefore served as a genetically tractable animal model for characterizing rapid …

Polyphosphoinositides are lipid signaling molecules generated from phosphatidylinositol
(PtdIns) with critical roles in vesicular trafficking and signaling. It is poorly understood where …

▪ Abstract The Drosophila phototransduction cascade has emerged as an attractive
paradigm for understanding the molecular mechanisms underlying visual transduction, as …