Flow fine synthesis with heterogeneous catalysts

K Masuda, T Ichitsuka, N Koumura, K Sato… - Tetrahedron, 2018 - Elsevier
In the past few decades, organic reactions under flow conditions have attracted increasing
attention. Flow reactions have a number of advantages over batch reactions in terms of …

Flow chemistry remains an opportunity for chemists and chemical engineers

RL Hartman - Current Opinion in Chemical Engineering, 2020 - Elsevier
Highlights•Flow chemistry has evolved from basic laboratory techniques to industrial
practice.•New avenues in reaction chemistry are expanding the molecular toolbox.•Next …

Heterogeneous catalysis for cross-coupling reactions: an underutilized powerful and sustainable tool in the fine chemical industry?

S Vásquez-Céspedes, RC Betori… - … Process Research & …, 2021 - ACS Publications
Transition-metal-catalyzed cross-coupling reactions are among the most important
processes in organic chemistry. For years, the fine chemical industry has looked for a variety …

Role of continuous flow processes in green manufacturing of pharmaceuticals and specialty chemicals

JA Bennett, ZS Campbell, M Abolhasani - Current Opinion in Chemical …, 2019 - Elsevier
Highlights•An overview of the elements of continuous flow processes.•Synopsis of recent
advancements in green continuous manufacturing strategies.•Synopsis of recent …

Palladium-scavenging self-assembled hybrid hydrogels–reusable highly-active green catalysts for Suzuki–Miyaura cross-coupling reactions

P Slavík, DW Kurka, DK Smith - Chemical science, 2018 - pubs.rsc.org
A hybrid hydrogel based on 1, 3: 2, 4-dibenzylidene sorbitol (DBS) modified with acyl
hydrazides combined with agarose was used for in situ reduction and binding of palladium …

Continuous flow (micro-) reactors for heterogeneously catalyzed reactions: Main design and modelling issues

I Rossetti - Catalysis Today, 2018 - Elsevier
Continuous flow chemistry is a rapidly developing branch in organic and drugs synthesis,
whereas it is common practice in heterogeneous catalysis for base chemicals production …

Rapid on-demand synthesis of lomustine under continuous flow conditions

Z Jaman, TJP Sobreira, A Mufti… - … Process Research & …, 2019 - ACS Publications
Lomustine, an important agent for treatment of brain tumors and Hodgkin's lymphoma, has
been synthesized using continuous flow methodology. Desorption electrospray ionization …

Exploring homogeneous conditions for mild Buchwald–Hartwig amination in batch and flow

SK Kashani, JE Jessiman… - … Process Research & …, 2020 - ACS Publications
Cross-couplings are among the most frequently used reactions in complex molecule
synthesis. However, the requirement of stoichiometric base can cause challenges. Harsh …

Combination of the Suzuki–Miyaura cross‐coupling reaction with engineered transaminases

AWH Dawood, J Bassut… - … A European Journal, 2018 - Wiley Online Library
The combination of enzymatic and chemical reaction steps is one important area of research
in organic synthesis, preferentially as cascade reactions in one‐pot to improve total …

Development and application of palladium nanoparticles on renewable polysaccharides as catalysts for the Suzuki cross-coupling of halobenzenes and …

A Wolfson, O Levy-Ontman - Molecular Catalysis, 2020 - Elsevier
In the nanotechnology era, the synthesis of nanoparticles plays a vital role in a wide range of
disciplinary fields. This review summarizes the more recent advances in the synthesis of …