Structural insights into nuclear transcription by eukaryotic DNA-dependent RNA polymerases
The eukaryotic transcription apparatus synthesizes a staggering diversity of RNA molecules.
The labour of nuclear gene transcription is, therefore, divided among multiple DNA …
The labour of nuclear gene transcription is, therefore, divided among multiple DNA …
Transcription termination by nuclear RNA polymerases
P Richard, JL Manley - Genes & development, 2009 - genesdev.cshlp.org
Gene transcription in the cell nucleus is a complex and highly regulated process.
Transcription in eukaryotes requires three distinct RNA polymerases, each of which employs …
Transcription in eukaryotes requires three distinct RNA polymerases, each of which employs …
Selective gene expression maintains human tRNA anticodon pools during differentiation
L Gao, A Behrens, G Rodschinka, S Forcelloni… - Nature Cell …, 2024 - nature.com
Transfer RNAs are essential for translating genetic information into proteins. The human
genome contains hundreds of predicted tRNA genes, many in multiple copies. How their …
genome contains hundreds of predicted tRNA genes, many in multiple copies. How their …
RNA polymerase III subunit mutations in genetic diseases
E Lata, K Choquet, F Sagliocco, B Brais… - Frontiers in Molecular …, 2021 - frontiersin.org
RNA polymerase (Pol) III transcribes small untranslated RNAs such as 5S ribosomal RNA,
transfer RNAs, and U6 small nuclear RNA. Because of the functions of these RNAs, Pol III …
transfer RNAs, and U6 small nuclear RNA. Because of the functions of these RNAs, Pol III …
Transcription termination by the eukaryotic RNA polymerase III
RNA polymerase (pol) III transcribes a multitude of tRNA and 5S rRNA genes as well as
other small RNA genes distributed through the genome. By being sequence-specific …
other small RNA genes distributed through the genome. By being sequence-specific …
RNA polymerase III transcription control elements: themes and variations
Eukaryotic genomes are punctuated by a multitude of tiny genetic elements, that share the
property of being recognized and transcribed by the RNA polymerase (Pol) III machinery to …
property of being recognized and transcribed by the RNA polymerase (Pol) III machinery to …
TFIIIC binding to Alu elements controls gene expression via chromatin looping and histone acetylation
How repetitive elements, epigenetic modifications, and architectural proteins interact
ensuring proper genome expression remains poorly understood. Here, we report regulatory …
ensuring proper genome expression remains poorly understood. Here, we report regulatory …
Regulation of pol III transcription by nutrient and stress signaling pathways
RD Moir, IM Willis - Biochimica et Biophysica Acta (BBA)-Gene Regulatory …, 2013 - Elsevier
Transcription by RNA polymerase III (pol III) is responsible for~ 15% of total cellular
transcription through the generation of small structured RNAs such as tRNA and 5S RNA …
transcription through the generation of small structured RNAs such as tRNA and 5S RNA …
A subcomplex of RNA polymerase III subunits involved in transcription termination and reinitiation
While initiation of transcription by RNA polymerase III (Pol III) has been thoroughly
investigated, molecular mechanisms driving transcription termination remain poorly …
investigated, molecular mechanisms driving transcription termination remain poorly …
Structural visualization of RNA polymerase III transcription machineries
Abstract RNA polymerase III (Pol III) transcription initiation requires the action of the
transcription factor IIIB (TFIIIB) and is highly regulated. Here, we determine the structures of …
transcription factor IIIB (TFIIIB) and is highly regulated. Here, we determine the structures of …