Red cell transfusion remains a critical component of care for acute and chronic
complications of sickle cell disease. Randomized clinical trials demonstrated the benefits of …

Sickle cell disease (SCD) is the most common life-threatening monogenic disorder in the
world. The disease is highly prevalent in malaria endemic areas with over 75% of patients …

Sickle cell disease (SCD) is the most common monogenic disorder in sub-Saharan Africa
(SSA). Blood transfusion to increase the oxygen carrying capacity of blood is vital in the …

Materials and Methods This case-control study included 253 SCD (153 SCD-transfused and
100 SCD non-transfused). We evaluated the transfusion practice (modalities, indications) …

Post-transfusion alloimmunisation is the main complication of all those observed after one or
more transfusion episodes. Alloimmunisation is observed after the transfusion of red blood …

Abstract Background Sub‐Saharan African countries face the challenge of immunological
transfusion safety that puts many patients at risk of post‐transfusion hemolytic reactions. This …

Millions are affected by sickle cell disease (SCD) worldwide with the greatest burden in sub-
Saharan Africa. While its origin lies historically within the malaria belt, ongoing changes in …

Red blood cell (RBC) transfusion is one of the most common medical treatments, with more
than 10 million units transfused per year in the United States alone. Alloimmunization to …

Background: Sickle cell disease (SCD) affects approximately 100,000 people in the United
States and millions worldwide, with the highest prevalence of 70% of SCD being found in …

Background Patients with sickle cell disease (SCD) are frequent recipients of red blood cell
(RBC) transfusions and are at risk for RBC alloimmunization. RBC alloimmunization is …