Intracellular human pathogens are the deadliest infectious diseases and pose great difficulty
to effectively treat due to their protection inside the host cell and the development of …

As a highly conserved, multifunctional protein with multiple domains, p62/SQSTM1 plays a
crucial role in several essential cellular activities, particularly selective autophagy. Recent …

Macrophage surface receptors are critical for pathogen defense, as they are the
gatekeepers for pathogen entry and sensing, which trigger robust immune responses …

Redox signaling is a fundamental mechanism that controls all major biological processes
partly via protein cysteine oxidations, including S-glutathionylation. Despite over 2000 …

Tuberculosis, a deadly infectious lung disease caused by Mycobacterium tuberculosis (Mtb),
remains the leading cause of bacterial disease-related deaths worldwide. Mtb reprograms …

Mycobacterium tuberculosis (Mtb), the infectious agent of tuberculosis (TB), causes over 1.5
million deaths globally every year. Host-directed therapies (HDT) for TB are desirable for …

Cell death and related signaling pathways are essential during development and in various
physiological and pathological conditions. Post-translational modifications such as …

The differentiation and activation of macrophages are critical regulatory programs that are
central to host inflammation and pathogen defense. However, the transcriptional regulatory …

Tuberculosis (TB) is a fatal infectious disease that continues to pose a serious public health
threat. The emergence of drug‐resistant TB has further worsened the burden of the disease …

Available mouse models for tuberculosis drug susceptibility testing requires using virulent
biosafety-level-3 (BSL-3) Mycobacterium tuberculosis (Mtb) strains, or attenuated BSL-2 …