[HTML][HTML] Approachable Synthetic Methodologies for Second-Generation β-Lactamase Inhibitors: A Review
Some antibiotics that are frequently employed are β-lactams. In light of the hydrolytic
process of β-lactamase, found in Gram-negative bacteria, inhibitors of β-lactamase (BLIs) …
process of β-lactamase, found in Gram-negative bacteria, inhibitors of β-lactamase (BLIs) …
Scalable synthesis of β-Lactamase inhibitor QPX7728 by sequential nickel-catalyzed boron insertion into a benzofuran substrate and enantioselective …
SH Boyer, A Gonzalez-de-Castro… - … Process Research & …, 2021 - ACS Publications
We report the scalable, high-yielding, and highly selective synthesis of the β-lactamase
inhibitor QPX7728 featuring two key synthetic steps: nickel-catalyzed boron insertion of …
inhibitor QPX7728 featuring two key synthetic steps: nickel-catalyzed boron insertion of …
Synthesis and Synergistic Antimicrobial Efficacy of Covalent Conjugates Composed of Epsilon-Poly-l-lysine and Beta-Lactam Antibiotics
S Chen, Y Qian, D Wan, Y Li, C Zhou - ACS Applied Bio Materials, 2024 - ACS Publications
The increasing severity of problems posed by drug-resistant pathogens has compelled
researchers to explore innovative approaches for infection prevention. Among these …
researchers to explore innovative approaches for infection prevention. Among these …
Piperacillin/tazobactam-resistant, cephalosporin-susceptible Escherichia coli bloodstream infections are driven by multiple acquisition of resistance across diverse …
Resistance to piperacillin/tazobactam (TZP) in Escherichia coli has predominantly been
associated with mechanisms that confer resistance to third-generation cephalosporins …
associated with mechanisms that confer resistance to third-generation cephalosporins …