Classically, the following three morphological states of microglia have been defined:
ramified, amoeboid and phagocytic. While ramified cells were long regarded as “resting” …

Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine encoded within a
functionally polymorphic genetic locus. MIF was initially recognized as a cytokine generated …

Aging results in gray and white matter degeneration, but the specific microglial responses
are unknown. Using single-cell RNA sequencing from white and gray matter separately, we …

Metastasis is the leading cause of cancer-related deaths and myeloid cells are critical in the
metastatic microenvironment. Here, we explore the implications of reprogramming pre …

Immune checkpoint therapies (ICT) can reinvigorate the effector functions of anti-tumour T
cells, improving cancer patient outcomes. Anti-tumour T cells are initially formed during their …

The brain microenvironment imposes a particularly intense selective pressure on metastasis-
initiating cells, but successful metastases bypass this control through mechanisms that are …

This review summarizes an expanding body of knowledge indicating that failure to resolve
inflammation and altered immune processes underlie the development of pulmonary arterial …

Sepsis and septic shock are among the leading causes of death in intensive care units
worldwide. Numerous studies on their pathophysiology have revealed an imbalance in the …

The past two decades have witnessed remarkable advances in oxidative stress research,
particularly in the context of ischemic brain injury. Oxidative stress in ischemic tissues …

Solid tumors consist of neoplastic cells, non-malignant stromal cells, and migratory
hematopoietic cells. Complex interactions between the cell types in this microenvironment …