The mammalian heart is responsible for not only pumping blood throughout the body but
also adjusting this pumping activity quickly depending upon sudden changes in the …

Obesity and atrial fibrillation have risen to epidemic levels worldwide and may continue to
grow over the next decades. Emerging evidence suggests that obesity promotes atrial and …

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) and higher
throughput platforms have emerged as potential tools to advance cardiac drug safety …

Slowly inactivating Na+ channels conducting “late” Na+ current (INa, late) contribute to
ventricular arrhythmogenesis under pathological conditions. INa, late was also reported to …

Ranolazine, an anti-anginal drug, is a late Na+ channel current blocker that is also believed
to attenuate fatty acid oxidation and mitochondrial respiratory complex I activity, especially …

Cardiac rhythms arise from electrical activity generated by precisely timed opening and
closing of ion channels in individual cardiac myocytes. These impulses spread throughout …

Ischemic heart disease is a significant public health problem with high mortality and
morbidity. Extensive scientific investigations from basic sciences to clinics revealed …

Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia in the clinical practice. It
significantly contributes to the morbidity and mortality of the elderly population. Over the past …

In February 2014, a group of scientists convened as part of the University of California Davis
Cardiovascular Symposium to bring together experimental and mathematical modelling …

The anti-arrhythmic efficacy of the late sodium channel current (late I Na) inhibition has been
convincingly demonstrated in the ventricles, particularly under conditions of prolonged …