Mass spectrometry (MS)-based proteomics is emerging as a broadly effective means for
identification, characterization, and quantification of proteins that are integral components of …

Ubiquitylation is among the most prevalent post‐translational modifications (PTM s) and
regulates numerous cellular functions. Interestingly, ubiquitin (Ub) can be itself modified by …

Heterotrimeric G proteins composed of Gα, Gβ, and Gγ subunits are vital eukaryotic
signaling elements that convey information from ligand-regulated G protein-coupled …

Ubiquitin is post-translationally modified by phosphorylation at several sites, but the
consequences of these modifications are largely unknown. Here, we synthesize multi …

Despite intense, continued interest in global analyses of signaling cascades through mass
spectrometry-based studies, the large-scale, systematic production of phosphoproteomics …

The ubiquitin–proteasome system (UPS) is the major intracellular degradation system, and
its proper function is critical to the health and function of cardiac cells. Alterations in cardiac …

Hyperactivated RAS drives progression of many human malignancies. However, oncogenic
activity of RAS is dependent on simultaneous inactivation of protein phosphatase 2A (PP2A) …

Analysis of differential abundance in proteomics data sets requires careful application of
missing value imputation. Missing abundance values widely vary when performing …

Whey proteins in bovine milk, as the most widely used nutritional components for infant
formulae, have been paid more attention. However, the phosphorylation of proteins in …

Transient Receptor Potential Canonical (TRPC) channels are homologues of Drosophila
TRP channel first cloned in mammalian cells. TRPC family consists of seven members which …