Cerebrovascular disease underpins vascular dementia (VaD), but structural and functional
changes to the cerebral vasculature contribute to disease pathology and cognitive decline in …

Since Late-onset Alzheimer's disease (LOAD) derives from a combination of genetic variants
and environmental factors, epigenetic modifications have been predicted to play a role in the …

Lysosome dysfunction arises early and propels Alzheimer's disease (AD). Herein, we show
that amyloid precursor protein (APP), linked to early-onset AD in Down syndrome (DS), acts …

Identification of Alzheimer's disease (AD) onset risk can facilitate interventions before
irreversible disease progression. We demonstrate that electronic health records from the …

Diabetic retinopathy (DR), one of the most common complications of diabetes mellitus, is
characterized by degeneration of retinal neurons and neoangiogenesis. Until today, the …

The past decade has witnessed increasing evidence for a crucial role played by glial cells,
notably astrocytes, in Alzheimer's disease (AD). To provide novel insights into the roles of …

Neurodegenerative diseases, including Alzheimer's disease (AD), are major contributors to
death and disability worldwide. A multitude of evidence suggests that neuroinflammation is …

Our understanding of lysosomes has undergone a significant transformation in recent years,
from the view that they are static organelles primarily responsible for the disposal and …

Alzheimer's disease (AD) is an insidious disease. Its distinctive pathology forms over a
considerable length of time without symptoms. There is a need to detect this disease, before …

Down syndrome (DS) is strongly associated with Alzheimer's disease (AD) due to APP
overexpression, exhibiting Amyloid-β (Aβ) and Tau pathology similar to early-onset (EOAD) …