Atomic force microscopy (AFM)-based methods have matured into a powerful nanoscopic
platform, enabling the characterization of a wide range of biological and synthetic …

Large conductance Ca 2+-and voltage-activated K+(BK) channels are widely distributed in
the postnatal central nervous system (CNS). BK channels play a pleiotropic role in …

We propose and present converging evidence for the Cytoelectric Coupling Hypothesis:
Electric fields generated by neurons are causal down to the level of the cytoskeleton. This …

The measurement of key molecules in individual cells with minimal disruption to the
biological milieu is the next frontier in single-cell analyses. Nanoscale devices are ideal …

Scanning ion conductance microscopy (SICM) has emerged as a versatile tool for studies of
interfaces in biology and materials science with notable utility in biophysical and …

The ability to study the molecular biology of living single cells in heterogeneous cell
populations is essential for next generation analysis of cellular circuitry and function. Here …

Rationale: Ca2+-induced Ca2+ release (CICR) in normal hearts requires close
approximation of L-type calcium channels (LTCCs) within the transverse tubules (T-tubules) …

The numbers and strengths of synapses in the brain change throughout development, and
even into adulthood, as synaptic inputs are added, eliminated, and refined in response to …

The role of voltage-gated Ca2+ channels (VGCCs) in spontaneous miniature
neurotransmitter release is incompletely understood. We found that stochastic opening of …

Dendritic spines are the primary site of excitatory synaptic input onto neurons, and are
biochemically isolated from the parent dendritic shaft by their thin neck. However, due to the …