Stimuli that promote cell migration, such as chemokines, cytokines, and growth factors in
metazoans and cyclic AMP in Dictyostelium, activate signaling pathways that control …

Loss of function of the PTEN tumour suppressor, resulting in dysregulated activation of the
phosphoinositide 3-kinase (PI3K) signalling network, is recognized as one of the most …

Chondroitin sulfate proteoglycans (CSPGs) are a family of extracellular matrix molecules
with various functions in regulating tissue morphogenesis, cell division, and axon guidance …

In vivo regeneration of peripheral neurons is constrained and rarely complete, and
unfortunately patients with major nerve trunk transections experience only limited recovery …

Semaphorins are secreted, transmembrane, and GPI-linked proteins, defined by cysteine-
rich semaphorin protein domains, that have important roles in a variety of tissues. Humans …

Semaphorin proteins, although initially characterized as repulsive neuronal guidance cues,
are now appreciated as major contributors to morphogenesis and homeostasis for a wide …

How axon regeneration is controlled in both PNS and CNS remains elusive. Mechanistic
studies of axon growth during development and axon regeneration after injury reveal the …

Semaphorins were initially characterized according to their role in repulsive axon guidance
but are now recognized as crucial regulators of morphogenesis and homeostasis over a …

The PTEN tumour suppressor is a lipid and protein phosphatase that inhibits
phosphoinositide 3-kinase (PI3K)-dependent signalling by dephosphorylating …

Plexin transmembrane receptors and their semaphorin ligands, as well as their co-receptors
(Neuropilin, Integrin, VEGFR2, ErbB2, and Met kinase) are emerging as key regulatory …