Highlights•HmuUV is the first structure of a heme uptake inner membrane ABC
transporter.•A novel assay was developed to assess in vitro heme uptake for …

Deviant levels of available heme and related molecules can result from pathological
situations such as impaired heme biosynthesis or increased hemolysis as a consequence of …

Heme is an iron-containing cofactor essential for multiple cellular processes and
fundamental activities such as oxygen transport. To better understand the means by which …

Iron scavenging constitutes a crucial challenge for survival of pathogenic microorganisms in
the iron-poor host environment. Candida albicans, like many microbial pathogens, is able to …

Endometriosis is an estrogen-dependent, progesterone-resistant gynecological disease with
an unknown pathogenesis. Compared to women without endometriosis, women with …

Abstract Progesterone Receptor Membrane Component 1 (PGRMC1) is located in many
different subcellular locations with many different attested and probably location-specific …

Progesterone receptor membrane component 1 (PGRMC1) is a 25 kDa protein with an N-
terminal transmembrane domain and a putative C-terminal cytochrome b5 domain. Heme …

Cytokines of the interleukin (IL)-1 family regulate immune and inflammatory responses. The
recently discovered IL-36 family members are involved in psoriasis, rheumatoid arthritis, and …

Pseudomonas aeruginosa is an opportunistic pathogen that utilizes heme as a primary iron
source within the host. Extracellular heme is sensed via a heme assimilation system (has) …

Background The occurrence of free organismal heme can either contribute to serious
diseases or beneficially regulate important physiological processes. Research on transient …