This article reviews the discovery of PCSK9, its structure–function characteristics, and its
presently known and proposed novel biological functions. The major critical function of …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) has evolved as a pivotal enzyme in
lipid metabolism and a revolutionary therapeutic target for hypercholesterolemia and its …

The biological functions of cholesterol are diverse, ranging from cell membrane integrity, cell
membrane signaling, and immunity to the synthesis of steroid and sex hormones, vitamin D …

Lowering blood cholesterol levels efficiently reduces the risk of developing atherosclerotic
cardiovascular disease (ASCVD), including coronary artery disease (CAD), which is the …

The gene encoding proprotein convertase subtilisin/kexin type 9 (PCSK9) and its protein
product have been widely studied for their role in cholesterol and lipid metabolism. PCSK9 …

Endothelial dysfunction often accompanies sepsis. We aimed to explore the role of PCSK9
in septic endothelial dysfunction. Sepsis was induced by lipopolysaccharide (LPS) treatment …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) reduces low density lipoprotein (LDL)
uptake, leading to increased plasma levels of LDL. In addition, PCSK9 has been implicated …

Azathioprine is used frequently to treat several inflammatory conditions. However, treatment
is limited by adverse events—in particular, myelotoxicity. Thiopurine‐S‐methyltransferase …

Sepsis is a life‐threatening organ dysfunction syndrome caused by a dysregulated host
response to infection. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is often …

Importance Observational studies suggest that statins, which inhibit 3-hydroxy-3-
methylglutaryl coenzyme A (HMG-CoA) reductase, may be associated with beneficial effects …