Charged and polar groups, through forming ion pairs, hydrogen bonds, and other less
specific electrostatic interactions, impart important properties to proteins. Modulation of the …

The association of histones with specific chaperone complexes is important for their folding,
oligomerization, post-translational modification, nuclear import, stability, assembly and …

Post-translational modifications of histones regulate all DNA-templated processes, including
replication, transcription and repair. These modifications function as platforms for the …

Nucleosomes are efficient DNA-packaging units. The fundamental protein unit of the
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …

Histone variants endow chromatin with unique properties and show a specific genomic
distribution that is regulated by specific deposition and removal machineries. These variants …

The compaction of genomic DNA into chromatin has profound implications for the regulation
of key processes such as transcription, replication and DNA repair. Nucleosomes, the …

Chromatin consists of a complex of DNA and histone proteins as its core components and
plays an important role in both packaging DNA and regulating DNA metabolic pathways …

Nucleosome assembly following DNA replication, DNA repair and gene transcription is
critical for the maintenance of genome stability and epigenetic information. Nucleosomes …

Stability and function of eukaryotic genomes are closely linked to chromatin structure and
organization. During cell division the entire genome must be accurately replicated and the …

A multitude of histone chaperones are required to support histones from their biosynthesis
until DNA deposition. They cooperate through the formation of histone co-chaperone …