The ageing population has been steadily increasing worldwide, leading to a higher risk of
cognitive decline and dementia. Environmental toxicants, particularly metals, have been …

Background: Parkinson's disease (PD) is a progressive neurodegenerative disease whose
main neuropathological feature is the loss of dopaminergic neurons of the substantia nigra …

Background: Iron is important in the pathophysiology of Parkinson's disease (PD)
specifically related to degeneration of the substantia nigra (SN). Magnetic resonance …

Parkinson's disease (PD) is one of the most common neurodegenerative diseases, most
commonly characterised by motor dysfunction, but also with a high prevalence of cognitive …

Parkinson's disease is a chronic, progressive neurodegenerative disorder affecting 2–3% of
the population≥ 65 years. It has long been characterized by motor impairment, autonomic …

Abstract Proton (1 H) Magnetic Resonance Spectroscopy (MRS) is a non-invasive tool
capable of quantifying brain metabolite concentrations in vivo. Prioritization of …

Inositols, regarded as a sugar-alcohol isomeric group, is a class of polyol compounds with
six-carbon ring structure and each carbon being hydroxylated. Among different biologically …

Iron deposition is crucial pathological changes observed in patients with Parkinson's
disease (PD). Recently, scientists have actively explored therapeutic approaches targeting …

ABSTRACT Background and Purpose Neurodegeneration of the substantia nigra in Lewy
body disease is associated with iron deposition, which increases the magnetic susceptibility …

Parkinson's disease (PD) is characterized by extrapyramidal motor disturbances and
nonmotor cognitive impairments which impact activities of daily living. Although the etiology …