miR-145 antagonizes SNAI1-mediated stemness and radiation resistance in colorectal cancer

Y Zhu, C Wang, SA Becker, K Hurst, LM Nogueira… - Molecular Therapy, 2018 - cell.com
Epithelial-to-mesenchymal transition (EMT) has been closely linked with therapy resistance
and cancer stem cells (CSCs). However, EMT pathways have proven challenging to …

Synthesis and pharmacological characterization of 2-aminobenzaldehyde oxime analogs as dual inhibitors of neutrophil elastase and proteinase 3

TL Hwang, WH Wang, TY Wang, HP Yu… - Bioorganic & Medicinal …, 2015 - Elsevier
Abstract Proteinase 3 (Pr3), and human neutrophil elastase (HNE) are two major
neutrophilic serine proteases (NsPs) expressed in neutrophil azurophil granules. Emerging …

[HTML][HTML] The trypsin inhibitor from Moringa oleifera flowers (MoFTI) inhibits acute inflammation in mice by reducing cytokine and nitric oxide levels

LL de Siqueira Patriota, DBM Ramos… - South African Journal of …, 2021 - Elsevier
The medicinal use of Moringa oleifera flowers to treat inflammations, for examples as
constituents of tonics, has been reported. Protease inhibitors isolated from plants have been …

Protease inhibitor from Libidibia ferrea seeds attenuates inflammatory and nociceptive responses in mice

R Carvalho, IS Bonfá, JAI Muller, SC Pando… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Libidibia ferrea (Mart. ex. Tul.) LP Queiroz is a
Brazilian native tree locally known as jucá and pau-ferro, and it has been used in folk …

Partial purification of trypsin/papain inhibitors from Hymenaea courbaril L. seeds and antibacterial effect of protein fractions

MS Brito, MB Melo, JPA Alves, ROS Fontenelle… - Hoehnea, 2016 - SciELO Brasil
RESUMO O extrato bruto e frações proteicas de sementes de Hymenaea courbaril foram
investigados para a presença de inibidores de tripsina e papaína e atividade antimicrobiana …

Bioengineering of an elastase inhibitor from Caesalpinia echinata (Brazil wood) seeds

I Cruz-Silva, AJ Gozzo, VA Nunes, AS Tanaka… - Phytochemistry, 2021 - Elsevier
Protease inhibitors have been widely used in several therapeutic applications such as in the
treatment of bleeding disorders, hypertension, cancer and pulmonary diseases. In a …

[图书][B] Natural Treatments for Lyme Coinfections: Anaplasma, Babesia, and Ehrlichia

SH Buhner - 2015 - books.google.com
A guide to the natural treatment of three coinfections of Lyme disease• Reviews the latest
scientific research on Babesia, Ehrlichia, and Anaplasma• Reveals how these three …

Viability of Brazilwood seeds (Caesalpinia echinata Lam.) stored at room temperature in controlled atmospheres

N Martini, CJ Barbedo - Journal of Seed Science, 2015 - SciELO Brasil
Seed storage at room temperature is an important and low-cost tool for ex situ conservation.
However, the high rates of seed deterioration could reduce the potential for storage in this …

Neutrophil elastase inhibitor purification strategy from cowpea seeds

GC Ferreira, AFA Duran, FRS da Silva, LM Bomediano… - Plos one, 2019 - journals.plos.org
Serine proteases and its inhibitors are involved in physiological process and its deregulation
lead to various diseases like Chronic Obstructive Pulmonary Disease (COPD), pulmonary …

Protease Inhibitors Extracted from Caesalpinia echinata Lam. Affect Kinin Release during Lung Inflammation

I Cruz-Silva, VA Nunes, AJ Gozzo… - Pulmonary …, 2016 - Wiley Online Library
Inflammation is an essential process in many pulmonary diseases in which kinins are
generated by protease action on kininogen, a phenomenon that is blocked by protease …