New appetite‐regulating antiobesity treatments such as semaglutide and agents under
investigation such as tirzepatide show promise in achieving weight loss of 15% or more …

Highlights•The cytochrome P450 4 (CYP4) family of enzymes is responsible for the
activation or deactivation of numerous endogenous substrates.•CYP4 is a vital therapeutic …

Variants of the G protein–coupled receptor 75 (GPR75) are associated with a lower BMI in
large-scale human exome-sequencing studies. However, how GPR75 regulates body …

Background Specialized pro-resolving mediators (SPMs), synthesized from PUFAs, resolve
inflammation and return damaged tissue to homeostasis. Thus, increasing metabolites of the …

Objective: This study aimed to explore the potential impact of pre-pregnancy and early
pregnancy maternal nutrition on the incidence of small-for-gestational-age neonates (SGA) …

Background and Purpose The G‐protein‐coupled receptor GPR75 (Gq) and its ligand, the
cytochrome P450‐derived vasoactive eicosanoid 20‐hydroxyeicosatetraenoic acid (20 …

Understanding lipid metabolism is a critical key to understanding the pathogenesis of
Diabetes Mellitus (DM). It is known that 60–90% of DM patients are obese or used to be …

In recent years, molecular targeted therapy has attracted more attention from researchers
due to its high efficiency and fewer side effects. Researchers are attempting to find more …

Objective Dyslipidemia, in particular elevated triglycerides (TGs) contribute to increased
cardiovascular risk in type 2 diabetes mellitus (T2DM). In this pilot study we aimed to assess …

Hydroxyeicosatetraenoic acids (HETEs) are metabolites of arachidonate acid (AA) oxidized
by lipoxygenases or cytochrome P450 enzymes (CYP450). Since lipoxygenases and …