The term autophagy encompasses different pathways that route cytoplasmic material to
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy …

Post-translational modifications, such as phosphorylation, ubiquitination and acetylation,
play crucial roles in the regulation of autophagy. Acetylation has emerged as an important …

Autophagy is a conserved lysosomal degradation pathway where cellular components are
dynamically degraded and re-processed to maintain physical homeostasis. However, the …

Impaired protein homeostasis and accumulation of damaged or abnormally modified protein
are common disease mechanisms in many neurodegenerative disorders, including …

The polyamines putrescine, spermidine, and spermine are abundant polycations of vital
importance in mammalian cells. Their cellular levels are tightly regulated by degradation …

Lysosomal acidification dysfunction has been implicated as a key driving factor in the
pathogenesis of neurodegenerative diseases, including Alzheimer's disease and …

Cells have developed elaborate quality-control mechanisms for proteins and organelles to
maintain cellular homeostasis. Such quality-control mechanisms are maintained by …

Abstract Parkinson's disease (PD), known as one of the most universal neurodegenerative
diseases, is a serious threat to the health of the elderly. The current treatment has been …

The fusion of autophagosomes and endosomes/lysosomes, also called autophagosome
maturation, ensures the degradation of autophagic cargoes. It is an important regulatory step …

Autophagy fights against harmful stimuli and degrades cytosolic macromolecules,
organelles, and intracellular pathogens. Autophagy dysfunction is associated with many …