Type 1 Diabetes (T1D) is one of the most common chronic autoimmune diseases in children.
The disease is characterized by the destruction of beta cells, leading to hyperglycemia, and …

Diabetes complications and osteoporotic fractures are two of the most important causes of
morbidity and mortality in older patients and share many features including genetic …

Diabetes involves the death or dysfunction of pancreatic β-cells. Analysis of bulk sequencing
from human samples and studies using in vitro and in vivo models suggest that endoplasmic …

Type 1 diabetes (T1D) culminates in the autoimmune destruction of the pancreatic βcells,
leading to insufficient production of insulin and development of hyperglycemia. Serum …

Bone fragility has emerged as a new complication of diabetes. Several mechanisms in
diabetes may influence bone homeostasis by impairing the action between osteoblasts …

Tissue inflammation results in the production of numerous reactive oxygen, nitrogen and
chlorine species, in addition to the products of lipid and sugar oxidation. Some of these …

Immunotherapies for type 1 diabetes mellitus (T1DM) have been the focus of intense basic
and clinical research over the past few decades. Restoring β-cell function is the ultimate …

Aim/hypothesis Insulin is the most specific beta cell antigen and a potential primary
autoantigen in type 1 diabetes. Insulin autoantibodies (IAAs) are the earliest marker of beta …

Highlights•Beta cells communicate with other endocrine cells and immune cells during the
course of T1D.•Beta cells contribute to their own demise by generating neoantigens targeted …

Purpose Bone formation is impaired in both type 1 diabetes and type 2 diabetes (T2D),
whereas sclerostin, an antagonist of bone formation, is increased in T2D only. No data are …