Discovery of STRO-002, a novel homogeneous ADC targeting folate receptor alpha, for the treatment of ovarian and endometrial cancers

X Li, S Zhou, CL Abrahams, S Krimm, J Smith… - Molecular Cancer …, 2023 - AACR
STRO-002 is a novel homogeneous folate receptor alpha (FolRα) targeting antibody–drug
conjugate (ADC) currently being investigated in the clinic as a treatment for ovarian and …

Quantitative imaging of receptor-ligand engagement in intact live animals

A Rudkouskaya, N Sinsuebphon, J Ward… - Journal of controlled …, 2018 - Elsevier
Maintaining an intact tumor environment is critical for quantitation of receptor-ligand
engagement in a targeted drug development pipeline. However, measuring receptor-ligand …

Light transport with weak angular dependence in fog

BZ Bentz, BJ Redman, JD van der Laan, K Westlake… - Optics …, 2021 - opg.optica.org
Random scattering and absorption of light by tiny particles in aerosols, like fog, reduce
situational awareness and cause unacceptable down-time for critical systems or operations …

Fabrication and application of heterogeneous printed mouse phantoms for whole animal optical imaging

BZ Bentz, AV Chavan, D Lin, EHR Tsai, KJ Webb - Applied optics, 2016 - opg.optica.org
This work demonstrates the usefulness of 3D printing for optical imaging applications.
Progress in developing optical imaging for biomedical applications requires customizable …

Theory of speckle intensity correlations over object position in a heavily scattering random medium

KJ Webb, Q Luo - Physical Review A, 2020 - APS
We present a general theory for optical imaging of moving objects obscured by heavily
scattering random media. Measurements involve collecting a series of speckle intensity …

Printed optics: phantoms for quantitative deep tissue fluorescence imaging

BZ Bentz, AG Bowen, D Lin, D Ysselstein, DH Huston… - Optics letters, 2016 - opg.optica.org
Three-dimensional (3D) printing allows for complex or physiologically realistic phantoms,
useful, for example, in developing biomedical imaging methods and for calibrating …

Superresolution diffuse optical imaging by localization of fluorescence

BZ Bentz, D Lin, KJ Webb - Physical Review Applied, 2018 - APS
The multiple scattering of light presents major challenges in realizing useful in vivo imaging
at tissue depths of more than about one millimeter, where many answers to health questions …

Diffuse optical localization of blood vessels and 3D printing for guiding oral surgery

BZ Bentz, TC Wu, V Gaind, KJ Webb - Applied optics, 2017 - opg.optica.org
Diffuse optical imaging through centimeters of tissue has emerged as a powerful tool in
biomedical research. However, applications in the operating theater have been limited in …

Multiresolution localization with temporal scanning for super-resolution diffuse optical imaging of fluorescence

BZ Bentz, D Lin, JA Patel… - IEEE Transactions on …, 2019 - ieeexplore.ieee.org
A super-resolution optical imaging method is presented that relies on the distinct temporal
information associated with each fluorescent optical reporter to determine its spatial position …

3D printed optical phantoms and deep tissue imaging for in vivo applications including oral surgery

BZ Bentz, A Costas, V Gaind… - Design and Quality …, 2017 - spiedigitallibrary.org
Progress in developing optical imaging for biomedical applications requires customizable
and often complex objects known as" phantoms" for testing, evaluation, and calibration. This …