Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …

Nucleotide-binding oligomerization domain (NOD)-like receptors, also known as nucleotide-
binding leucine-rich repeat receptors (NLRs), are a family of cytosolic pattern recognition …

Cytosolic innate immune sensors are critical for host defense and form complexes, such as
inflammasomes and PANoptosomes, that induce inflammatory cell death. The sensor …

NLRP1 and CARD8 are related pattern-recognition receptors (PRRs) that detect intracellular
danger signals and form inflammasomes. Both undergo autoproteolysis, generating N …

The danger signals that activate the related nucleotide-binding domain leucine-rich repeat
pyrin domain-containing 1 (NLRP1) and caspase activation and recruitment domain …

Redox imbalance is defined by disruption in oxidative and reductive pathways and has a
central role in cancer initiation, development, and treatment. Although redox imbalance has …

Mounting evidence indicates that proteotoxic stress is a primary activator of the CARD8
inflammasome, but the complete array of signals that control this inflammasome have not yet …