G protein coupled receptors are responsible for a wide variety of signaling responses in
diverse cell types. Despite major advances in the determination of structures of this class of …

The past decade has witnessed fluorescently tagged drug molecules gaining significant
attraction in their use as pharmacological tools with which to visualize and interrogate …

Hydrogen sulfide (H2S) is an important gaseous signaling agent mediated by many
physiological processes and diseases. In order to explore its role in biological signaling …

The histamine H1-receptor (H1R) is an important mediator of allergy and inflammation. H1R
antagonists have particular clinical utility in allergic rhinitis and urticaria. Here we have …

Introduction: G-protein-coupled receptors (GPCRs) mediate the effects of approximately
33% of all marketed drugs. The development of tools to study GPCR pharmacology is …

Abstract Scientists Robert J. Lefkowitz and Brian K. Kobilka won the Nobel Prize in 2012 for
reporting a groundbreaking discovery that revealed a crucial member of the receptor family …

G-protein-coupled receptors (GPCRs), a superfamily of cell-surface receptors that are the
targets of about 40% of prescription drugs on the market, can sense numerous critical …

Serotonin (5-HT) modulates key aspects of the immune system. However, its precise
function and the receptors involved in the observed effects have remained elusive. Among …

Serotonin is a neurotransmitter that plays a crucial role in the regulation of several
behavioral and cognitive functions by binding to a number of different serotonin receptors …

The robust of fluorescent techniques to study the ligand-receptor interaction followed by
rapidly developing fluorescence imaging techniques resulted in a burst of the novel …