Abstract Preterm birth (PTB) complicates 5–18% of pregnancies globally and is a leading
cause of maternal and fetal morbidity and mortality. Most PTB is spontaneous and idiopathic …

The complement cascade was identified over 100 years ago, yet investigation of its role in
pregnancy remains an area of intense research. Complement inhibitors at the maternal-fetal …

Objective: The objectives of this study were to:(1) determine the amniotic fluid (AF)
microbiology of patients with preterm prelabor rupture of membranes (PROM); and (2) …

There has been a surge in studies implicating a role of vaginal microbiota in spontaneous
preterm birth (sPTB), but most are associative without mechanistic insight. Here we show a …

Objective Although a higher maternal body mass index is associated with preterm birth, it is
unclear whether excess gestational weight gain (GWG) or obesity drives increased risk. We …

Problem The diagnosis of microbial invasion of the amniotic cavity (MIAC) has been
traditionally performed using traditional cultivation techniques, which require growth of …

Objective: Preterm birth is associated with 5–18% of pregnancies and is the leading cause
of neonatal morbidity and mortality. Amniotic fluid (AF) interleukin-6 (IL-6) is a key cytokine …

Inflammation is frequently linked to preterm delivery (PTD). Here, we tested the hypothesis
that complement activation plays a role in cervical remodeling and PTD. We studied two …

Aims: To characterize the transcriptome of human myometrium during spontaneous labor at
term. Methods: Myometrium was obtained from women with (n= 19) and without labor (n …

Objective. Biomarkers for preterm labor (PTL) and delivery can be discovered through the
analysis of the transcriptome (transcriptomics) and protein composition (proteomics) …