The progressive loss of skeletal muscle mass and concomitant reduction in contractile
strength plays a central role in frailty syndrome. Age-related neuronal impairments are …

Skeletal muscle shows high plasticity in response to external demand. Moreover, adult
skeletal muscle is capable of complete regeneration after injury, due to the properties of …

Tumour cells exhibit greater metabolic plasticity than normal cells and possess selective
advantages for survival and proliferation with unclearly defined mechanisms. Here we …

Skeletal muscle is a tissue with a low mitochondrial content under basal conditions, but it is
responsive to acute increases in contractile activity patterns (ie exercise) which initiate the …

For centuries, regular exercise has been acknowledged as a potent stimulus to promote,
maintain, and restore healthy functioning of nearly every physiological system of the human …

Abstract Skeletal muscle makes up 30–40% of the total body mass. It is of great significance
in maintaining digestion, inhaling and exhaling, sustaining body posture, exercising …

Age-related loss of skeletal muscle mass and function is a major contributor to morbidity and
has a profound effect on the quality of life of older people. The potential role of age …

Background: Tendon injuries are one of the most common musculoskeletal conditions in
active patients. Platelet-rich plasma (PRP) has shown some promise in the treatment of …

Myosteatosis is the pathologic accumulation of lipid that can occur in conjunction with
atrophy and fibrosis following skeletal muscle injury. Little is known about the mechanisms …

Testing the predictions of the Mitochondrial Free Radical Theory of Ageing (MFRTA) has
provided a deep understanding of the role of reactive oxygen species (ROS) and …