Abstract Streptococcus pyogenes (Group A Streptococcus; GAS) is exquisitely adapted to
the human host, resulting in asymptomatic infection, pharyngitis, pyoderma, scarlet fever or …

The use of antibiotics has enabled the successful treatment of bacterial infections, saving the
lives and improving the health of many patients worldwide. However, the emergence and …

Streptococcus pyogenes, also known as group A Streptococcus (GAS), causes mild human
infections such as pharyngitis and impetigo and serious infections such as necrotizing …

Recent efforts have re-invigorated the Streptococcus pyogenes (Group A Streptococcus)
vaccine development field, though scientific, regulatory and commercial barriers persist, and …

Abstract Background. Invasive group A Streptococcus (GAS) infections are associated with
significant morbidity and mortality rates. We report the epidemiology and trends of invasive …

Acute rheumatic fever is caused by an autoimmune response to throat infection with
Streptococcus pyogenes. Cardiac involvement during acute rheumatic fever can result in …

Rheumatic heart disease, often neglected by media and policy makers, is a major burden in
developing countries where it causes most of the cardiovascular morbidity and mortality in …

Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) are significant public
health concerns around the world. Despite decreasing incidence, there is still a significant …

Abstract Group A Streptococcus (GAS; Streptococcus pyogenes) is a bacterial pathogen for
which a commercial vaccine for humans is not available. Employing the advantages of high …

Summary emm sequence typing is the most widely used method for defining group A
streptococcal (GAS) strains, and has been applied to isolates in all regions of the world. We …