Paradigms of acute kidney injury in the intensive care setting

JA Kellum, JR Prowle - Nature Reviews Nephrology, 2018 - nature.com
Acute kidney injury (AKI) is a heterogeneous clinical syndrome that has multiple aetiologies,
variable pathogenesis and diverse outcomes. However, these heterogeneities are not …

Long-term effects of severe burns on the kidneys: research advances and potential therapeutic approaches

G Yang, L Tan, H Yao, Z Xiong, J Wu… - Journal of Inflammation …, 2023 - Taylor & Francis
Burns are a seriously underestimated form of trauma that not only damage the skin system
but also cause various complications, such as acute kidney injury (AKI). Recent clinical …

Immunopathology of acute kidney injury in severe malaria

O Katsoulis, A Georgiadou, AJ Cunnington - Frontiers in Immunology, 2021 - frontiersin.org
Acute kidney injury (AKI) is a common feature of severe malaria, and an independent risk
factor for death. Previous research has suggested that an overactivation of the host …

Methylation in pericytes after acute injury promotes chronic kidney disease

YH Chou, SY Pan, YH Shao, HM Shih… - The Journal of …, 2020 - Am Soc Clin Investig
The origin and fate of renal myofibroblasts is not clear after acute kidney injury (AKI). Here,
we demonstrate that myofibroblasts were activated from quiescent pericytes (qPericytes) …

Impact of angiotensin-converting enzyme inhibitors or receptor blockers on post-ICU discharge outcome in patients with acute kidney injury

E Gayat, A Hollinger, A Cariou, N Deye… - Intensive care …, 2018 - Springer
Purpose Acute kidney injury (AKI) is associated with the activation of the renin–angiotensin
system. Whether angiotensin-converting enzyme inhibitors (ACEi) or angiotensin-receptor …

Protective Effect of Sex Hormone‐Binding Globulin against Metabolic Syndrome: In Vitro Evidence Showing Anti‐Inflammatory and Lipolytic Effects on Adipocytes …

H Yamazaki, A Kushiyama, H Sakoda… - Mediators of …, 2018 - Wiley Online Library
Sex hormone‐binding globulin (SHBG) is a serum protein released mainly by the liver, and
a low serum level correlates with a risk for metabolic syndrome including diabetes, obesity …

Role of renal hypoxia in the progression from acute kidney injury to chronic kidney disease

MM Ullah, DP Basile - Seminars in nephrology, 2019 - Elsevier
Over the past 20 years, there has been an increased appreciation of the long-term sequelae
of acute kidney injury (AKI) and the potential development of chronic kidney disease (CKD) …

[HTML][HTML] Update of pericytes function and their roles in kidney diseases

YH Chou, SY Pan, HM Shih, SL Lin - Journal of the Formosan Medical …, 2024 - Elsevier
Studies have highlighted the significant involvement of kidney pericytes in renal fibrosis.
Kidney pericytes, classified as interstitial mesenchymal cells, are extensively branched …

Renin-angiotensin system blockade after acute kidney injury (AKI) and risk of recurrent AKI

C Hsu, KD Liu, J Yang, DV Glidden… - Clinical Journal of the …, 2020 - journals.lww.com
Results Forty-seven percent of the study population had a documented eGFR< 60 ml/min
per 1.73 m 2 or documented proteinuria before hospitalization. With a median of 3 …

[HTML][HTML] Acute kidney disease: an overview of the epidemiology, pathophysiology, and management

CW Kung, YH Chou - Kidney Research and Clinical Practice, 2023 - ncbi.nlm.nih.gov
Acute kidney injury (AKI) increases the risk of chronic kidney disease (CKD), and AKI and
CKD are seen as interconnected syndromes. Acute kidney disease (AKD) is defined as …