Cerebral malaria: mechanisms of brain injury and strategies for improved neurocognitive outcome

R Idro, K Marsh, CC John, CRJ Newton - Pediatric research, 2010 - nature.com
Cerebral malaria is the most severe neurological complication of infection with Plasmodium
falciparum. With> 575,000 cases annually, children in sub-Saharan Africa are the most …

The'hidden'burden of malaria: cognitive impairment following infection

SD Fernando, C Rodrigo, S Rajapakse - Malaria journal, 2010 - Springer
Background The burden of post-malaria cognitive impairment is often overlooked. Given the
large number of infections occurring worldwide, the magnitude of the problem is likely to be …

Cerebral malaria in children is associated with long-term cognitive impairment

CC John, P Bangirana, J Byarugaba, RO Opoka… - …, 2008 - publications.aap.org
OBJECTIVE. Cerebral malaria affects> 785000 African children every year. We previously
documented an increased frequency of cognitive impairment in children with cerebral …

CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature

PA Swanson, GT Hart, MV Russo, D Nayak… - PLoS …, 2016 - journals.plos.org
Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection that
results in thousands of deaths each year, mostly in African children. The in vivo mechanisms …

Activated brain endothelial cells cross-present malaria antigen

SW Howland, CM Poh, L Rénia - PLoS pathogens, 2015 - journals.plos.org
In the murine model of cerebral malaria caused by P. berghei ANKA (PbA), parasite-specific
CD8+ T cells directly induce pathology and have long been hypothesized to kill brain …

Nitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology

P Cabrales, GM Zanini, D Meays… - Journal of Infectious …, 2011 - academic.oup.com
Cerebral malaria (CM) is a leading cause of death in Plasmodium falciparum infections. In
the Plasmodium berghei ANKA (PbA) murine model, CM pathogenesis is associated with …

Experimental cerebral malaria pathogenesis—hemodynamics at the blood brain barrier

A Nacer, A Movila, F Sohet, NM Girgis… - PLoS …, 2014 - journals.plos.org
Cerebral malaria claims the lives of over 600,000 African children every year. To better
understand the pathogenesis of this devastating disease, we compared the cellular …

Antiplasmodial and interferon-gamma-modulating activities of the aqueous extract of stone breaker (Phyllanthus niruri Linn.) in malaria infection

TO Jeje, H Bando, MTA Azad, Y Fukuda… - Parasitology …, 2023 - Elsevier
Plasmodium falciparum parasites are the primary cause of malaria across Africa. The
problem of drug resistance to malaria is ever growing and novel therapeutic strategies need …

[HTML][HTML] Dysregulation of coagulation in cerebral malaria

CA Moxon, RS Heyderman, SC Wassmer - Molecular and biochemical …, 2009 - Elsevier
Cerebral malaria (CM) is a life-threatening complication of Plasmodium falciparum infection
and represents a major cause of morbidity and mortality worldwide. The nature of the …

Unraveling cell death pathways during malaria infection: what do we know so far?

C Sena-dos-Santos, C Braga-da-Silva, D Marques… - Cells, 2021 - mdpi.com
Malaria is a parasitic disease (caused by different Plasmodium species) that affects millions
of people worldwide. The lack of effective malaria drugs and a vaccine contributes to this …