Laboratory investigations provide physicians with objective data to aid in disease diagnosis,
clinical decision making, and patient follow up. Clinical interpretation of laboratory test …

Improved outcomes for many types of cancer achieved during recent years is due, among
other factors, to the earlier detection of tumours and the greater availability of screening …

Reference intervals are essential for the interpretation of laboratory test results in medicine.
We propose a novel indirect approach to estimate reference intervals from real-world data …

The history of the theory of reference values can be written as an unfinished symphony. The
first movement, allegro con fuoco, played from 1960 to 1980: a mix of themes devoted to the …

Background Serum lipid concentrations are thought to be risk factors for the development of
cardiovascular disease. The present study aims to investigate the prevalence of …

Background Gender-specific differences in hypothalamus–pituitary–adrenal (HPA) axis
activity have been postulated to emerge during puberty. We conducted a systematic review …

Pathogenic bacterial contamination greatly threats human health and safety. Rapidly
biosensing pathogens in the early stage of infection would be helpful to choose the correct …

Background: Determination of pediatric reference intervals (RIs) for laboratory quantities,
including hematological quantities, is complex. The measured quantities vary by age, and …

Paediatric reference intervals based on samples from healthy children are difficult to
establish and consequently data are often from hospitalized children. Furthermore, biases …

Background: Reported cutoffs for childhood thyrotropin (TSH) and free thyroxine (fT4)
reference ranges vary widely, and knowledge on the determinants of childhood thyroid …