This review outlines the molecular sensors that reprogram cellular metabolism in response
to the ketogenic diet (KD). Special emphasis is placed on the fasting-, fatty acid-and drug …

Although most screening for new drug leads is being directed at known or emerging
molecular targets, there has been a renaissance in screening based on changes in cell or …

Although evidences are emerging that dietary isoflavones have beneficial effects in
treatment of hyperlipidemia and cardiovascular diseases, the underlying molecular …

Abstract Fenofibrate, an agonist of PPAR-alpha, in doses above 25 μM, inhibits proliferation
and induces apoptosis in Ishikawa endometrial cancer cells. We show that these effects are …

Background Several glitazones (PPARγ agonists) and glitazars (dual PPARα/γ agonists)
have been developed to treat hyperglycemia and, simultaneously, hyperglycemia and …

Drug-induced myopathies and, more rarely, rhabdomyolysis, are a common biological and
clinical setting for clinical rheumatologists. The focus of this chapter is to review (i) the …

Peroxisome proliferator-activated receptor (PPAR)-α controls the transcription of a variety of
genes involved in lipid metabolism and is the target receptor for the hypolipidemic drug …

Advances in the rapidly evolving discipline of pharmacogenomics have forced the
biotechnology and pharmaceutical industries to integrate differential gene expression …

Perfluoroalkyl acids (PFAAs) such as perfluorooctane sulfonate (PFOS) and
perfluorooctanoic acid (PFOA) are developmental toxicants in various animal classes …

Adrenoleukodystrophy protein (ABCD1), a peroxisomal membrane protein, is mutated in
patients affected by X-linked adrenoleukodystrophy (X-ALD). Adrenoleukodystrophy-related …