Neuroinflammatory processes are a central feature of Alzheimer's disease (AD) in which
microglia are over-activated, resulting in the increased production of pro-inflammatory …

Hepatocellular carcinoma (HCC), the predominant type of primary liver cancer, is one of the
most serious life-threatening malignancies, worldwide. In majority of the cases, HCC …

We performed a multitiered, case-control association study of psoriasis in three independent
sample sets of white North American individuals (1,446 cases and 1,432 controls) with …

Takayasu arteritis (TAK) is an autoimmune systemic vasculitis of unknown etiology. Although
previous studies have revealed that HLA-B∗ 52: 01 has an effect on TAK susceptibility, no …

In an attempt both to catalogue 3′ regulatory region (3′ RR)-mediated disease and to
improve our understanding of the structure and function of the 3′ RR, we have performed a …

Objective To investigate the-1082 (A/G) polymorphism in the promoter of the IL-10 gene in
terms of IL-10 production from stimulated peripheral blood mononuclear cells (PBMC) and to …

Identification of host genetic determinants of measles vaccine-induced immunity can be
used to design better vaccines and ultimately predict immune responses to vaccination. We …

Talk of numerous genetic risk factors for rheumatoid arthritis (RA) and psoriasis has been
percolating for years, but with the exception of the human leukocyte antigen (HLA) region …

Background: The gene polymorphisms interferon‐gamma (IFN‐γ) 874 T/A and interleukin
(IL)‐12 1188 A/C have been associated with the altered production of cytokines. Therefore …

Increasing evidence has indicated that genetic variants may contribute to immune
dysregulation and susceptibility to noninfectious inflammatory diseases. Cytokines …