Supercritical antisolvent process for pharmaceutical applications: A review

P Franco, I De Marco - Processes, 2020 - mdpi.com
The supercritical antisolvent (SAS) technique has been widely employed in the biomedical
field, including drug delivery, to obtain drug particles or polymer-based systems of …

Nanoparticles and Nanocrystals by Supercritical CO2-Assisted Techniques for Pharmaceutical Applications: A Review

P Franco, I De Marco - Applied Sciences, 2021 - mdpi.com
Many active ingredients currently prescribed show limited therapeutic efficacy, mainly due to
their dissolution rate inadequate to treat the pathology of interest. A large drug particle size …

Particle preparation of pharmaceutical compounds using supercritical antisolvent process: current status and future perspectives

R Kumar, AK Thakur, G Kali, KC Pitchaiah… - Drug Delivery and …, 2023 - Springer
The low aqueous solubility and subsequently slow dissolution rate, as well as the poor
bioavailability of several active pharmaceutical ingredients (APIs), are major challenges in …

Interactions between whey proteins and calcium salts and implications for the formulation of dairy protein‐based nutritional beverage products: A review

G Barone, J O'Regan, AL Kelly… - … Reviews in Food …, 2022 - Wiley Online Library
Whey‐based nutritional beverages are often fortified with calcium (Ca) in order to deliver the
recommended intake of Ca. However, technical and product quality challenges are often …

Preparation, characterization and evaluation of the antioxidant capacity and antitumor activity of myricetin microparticles formated by supercritical antisolvent …

T Yan, Y Tao, X Wang, C Lv, G Miao, S Wang… - The Journal of …, 2021 - Elsevier
Myricetin (MYR) shows a lot of pharmacological activity such as antioxidant capacity and
antitumor activity. However, the poor aqueous solubility of MYR (2 μg/mL) limits its …

Development of nanoparticles for pharmaceutical preparations using supercritical techniques

T Islam, A Al Ragib, S Ferdosh… - Chemical …, 2022 - Taylor & Francis
This review focuses on nanoparticle (NP) synthesis and particle size design using
supercritical fluid (SCF) technology for pharmaceutical formulations. SCF technology is seen …

Formation of fine particles from curcumin/PVP by the supercritical antisolvent process with a coaxial nozzle

S Machmudah, S Winardi, Wahyudiono, H Kanda… - ACS …, 2020 - ACS Publications
The production of fine particles via the supercritical carbon dioxide (SC–CO2) antisolvent
process was carried out. The experiments were conducted at temperatures of 40–60° C and …

Anti-solvent crystallization of celecoxib in the presence of PVP for enhancing the dissolution rate: Comparison of water and supercritical CO2 as two antisolvents

F Sadeghi, Z Soleimanian, F Hadizadeh… - … Research and Design, 2022 - Elsevier
For dissolution enhancement of celecoxib (CLX), an anti-solvent crystallization technique in
the presence of polyvinylpyrrolidone (PVP) was applied by either water (WAS), a …

Encapsulation and Delivery of Nutraceuticals and Bioactive Compounds by Nanoliposomes and Tocosomes as Promising Nanocarriers

N Shahgholian - Handbook of Nutraceuticals and Natural …, 2022 - Wiley Online Library
The term “nutraceutical” was coined in 1989 by the Foundation for Innovation in Medicine
(New York, US; an educational foundation to encourage discoveries in medicine). A …

[HTML][HTML] CO2 utilization as a gas antisolvent in the production of glibenclamide nanoparticles, glibenclamide-HPMC, and glibenclamide-PVP composites

SA Sajadian, N Esfandiari, L Padrela - Journal of CO2 Utilization, 2024 - Elsevier
Glibenclamide is an antidiabetic drug that also acts as an anti-inflammatory factor and
reduces oxidative stress, medullary edema, and heart attack. Glibenclamide has high …