A functional immune system requires the selection of T lymphocytes expressing receptors
that are major histocompatibility complex restricted but tolerant to self-antigens. This …

The lymphoid tissues associated with the intestine are exposed continuously to antigen and
are the largest part of the immune system. Many lymphocytes are found in organised tissues …

TCRαβ thymocytes differentiate into either CD8αβ+ cytotoxic T lymphocytes or CD4+ helper
T cells. This functional dichotomy is controlled by key transcription factors, including the …

Locally resident intraepithelial lymphocytes (IELs) are primarily T cells with potent cytolytic
and immunoregulatory capacities, which they use to sustain epithelial integrity. Here, we …

The origin and specificity of αβ TCR+ T cells that express CD8αα have been controversial
issues. Here we provide direct evidence that precursors of functional CD8αα T cells are …

There is an immense load of non-pathogenic commensal bacteria in the distal small
intestine and the colon of mammals. The physical barrier that prevents penetration …

Mouse small intestine intraepithelial lymphocytes (IEL) that express αβTCR and CD8αα
homodimers are an enigmatic T cell subset, as their specificity and in vivo function remain to …

Expression of the BY55 protein has been shown to be tightly associated with NK and CD8+
T lymphocytes with cytolytic effector activity. To determine the function of this protein, we …

The CD8 T cell response to vesicular stomatitis virus infection was characterized in the
spleen and intestinal mucosa using MHC tetramers. Surprisingly, the primary response …

Proper thymocyte development is required to establish T-cell central tolerance and to
generate naive T cells, both of which are essential for T-cell homeostasis and a functional …