Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis
where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

Tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) can induce apoptosis
in a wide variety of cancer cells, both in vitro and in vivo, importantly without killing any …

The discovery that the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) can
induce apoptosis of cancer cells without causing toxicity in mice has led to the in-depth study …

Neuroinflammation is central to the common pathology of several acute and chronic brain
diseases. This review examines the consequences of excessive and prolonged …

Unlike other members of the TNF superfamily, the TNF-related apoptosis-inducing ligand
(TRAIL, also known as Apo2L) possesses the unique capacity to induce apoptosis …

Apoptosis—the regulated destruction of a cell—is a complicated process. The decision to
die cannot be taken lightly, and the activity of many genes influence a cell's likelihood of …

Two different tumour-necrosis factors (TNFs), first isolated in 1984, were found to be
cytotoxic to tumour cells and to induce tumour regression in mice. Research during the past …

A single mouse click on the topic tumor necrosis factor (TNF) in PubMed reveals about 50
000 articles providing one or the other information about this pleiotropic cytokine or its …