Emerging data suggest that ApoE affects several amyloid β-independent pathways. These
underexplored pathways may provide new insights into Alzheimer's disease pathogenesis …

Liver X receptors (LXRs) are master regulators of cholesterol homeostasis and inflammation
in the central nervous system (CNS). The brain, which contains a disproportionately large …

A major issue in clinical endocrinology today is how to use hormones to achieve the health
benefits that they clearly can provide but avoid the negative side effects, that is, how to …

The brain's choroid plexus (CP), which operates as an anatomical and functional
'checkpoint', regulates the communication between brain and periphery and contributes to …

Mature multiciliated ependymal cells line the cerebral ventricles where they form a partial
barrier between the cerebrospinal fluid (CSF) and brain parenchyma and regulate local CSF …

The liver X receptor (LXR) is a key transcriptional regulator of cholesterol, fatty acid, and
phospholipid metabolism. Dynamic remodeling of immunometabolic pathways, including …

Tuberculous meningitis (TBM) is the most severe and deadly manifestation of tuberculosis.
Neurological complications are observed in up to 50% of patients affected. Here, attenuated …

Liver X receptors (LXRα and LXRβ) are oxysterol-activated nuclear receptors that play key
roles in cholesterol homeostasis, the central nervous system, and the immune system. We …

In this review, we discuss the role of liver X receptors (LXRs) in glial cells (microglia,
oligodendrocytes and astrocytes) in the central nervous system (CNS). LXRs are oxysterol …

The etiology of peripheral squamous cell lung cancer (PSCCa) remains unknown. Here, we
show that this condition spontaneously develops in mice in which the genes for two …