Mitochondrial energetic adaptations encompass a plethora of conserved processes that
maintain cell and organismal fitness and survival in the changing environment by adjusting …

In 1971, Gunter Blobel and David Sabatini published the first report of the signal hypothesis
where they propose that proteins contain information within their amino acid sequences for …

The presequence translocase of the mitochondrial inner membrane (TIM23) represents the
major route for the import of nuclear-encoded proteins into mitochondria,. About 60% of …

The yeast silent information regulator (Sir) 2 protein links cellular metabolism and
transcriptional silencing through its nicotinamide adenine dinucleotide (NAD)-dependent …

Most mitochondrial proteins are synthesized in the cytosol as precursor proteins with a
cleavable N-terminal presequence and are imported into mitochondria. We report here the …

Representative samples of mitochondrial and chloroplast targetting peptides have been
analyzed in terms of amino acid composition, positional amino acid preferences and …

Sirtuins are homologues of the yeast transcriptional repressor Sir2p and are conserved from
bacteria to humans. We report that human SIRT4 is localized to the mitochondria. SIRT4 is a …

SUMMARY ATP synthase, a double-motor enzyme, plays various roles in the cell,
participating not only in ATP synthesis but in ATP hydrolysis-dependent processes and in …

The cytochrome bc1 complex is the most widely occurring electron transfer complex capable
of energy transduction. Cytochrome bc1 complexes are found in the plasma membranes of …

The preprotein translocase of the outer mitochondrial membrane (Tom) is a multi-subunit
complex required for specific recognition and membrane translocation of nuclear-encoded …