Shortly after John Eccles completed his studies of synaptic inhibition in the spinal cord, for
which he was awarded the 1963 Nobel Prize in physiology/medicine, he opened another …

Cerebellar Purkinje cells exhibit a unique type of synaptic plasticity, namely, long-term
depression (LTD). When two inputs to a Purkinje cell, one from a climbing fiber and the other …

▪ Abstract The cerebellum is an evolutionarily conserved structure critical for motor learning
in vertebrates. The model that has influenced much of the work in the field for the past 30 …

Over the past few years, a wealth of biochemical and functional data have been gathered on
mammalian cGMP-dependent protein kinases (cGKs). In mammals, three different kinases …

The notion that the olivocerebellar system is crucial for motor learning is well established. In
recent years, it has become evident that there can be many forms of both synaptic and non …

Adaptation of ocular reflexes is a prototype of motor learning. While the cerebellum is
acknowledged as the critical site for motor learning, the functional differences between the …

The second messenger cyclic guanosine 3′, 5′-monophosphate (cGMP) plays a crucial
role in the control of cardiovascular and gastrointestinal homeostastis, but its effects on …

Abstract Hydrogen Sulfide (H 2 S) and Nitric Oxide (NO) have become recognized as
important gaseous signaling molecules with enormous pharmacological effects, therapeutic …

Long-term depression (LTD) here concerned is persistent attenuation of transmission
efficiency from a bundle of parallel fibers to a Purkinje cell. Uniquely, LTD is induced by …

The molecular basis for cerebellar plasticity and motor learning remains controversial.
Cerebellar Purkinje cells (PCs) contain a high concentration of cGMP-dependent protein …