Metabolomics in the context of plant natural products research: From sample preparation to metabolite analysis

MA Salem, L Perez de Souza, A Serag, AR Fernie… - Metabolites, 2020 - mdpi.com
Plant-derived natural products have long been considered a valuable source of lead
compounds for drug development. Natural extracts are usually composed of hundreds to …

[HTML][HTML] The food metabolome: a window over dietary exposure

A Scalbert, L Brennan, C Manach… - The American journal of …, 2014 - Elsevier
The food metabolome is defined as the part of the human metabolome directly derived from
the digestion and biotransformation of foods and their constituents. With> 25,000 …

The strengths and weaknesses of NMR spectroscopy and mass spectrometry with particular focus on metabolomics research

AHM Emwas - Metabonomics: Methods and protocols, 2015 - Springer
Mass spectrometry (MS) and nuclear magnetic resonance (NMR) have evolved as the most
common techniques in metabolomics studies, and each brings its own advantages and …

Analysis of wild tomato introgression lines elucidates the genetic basis of transcriptome and metabolome variation underlying fruit traits and pathogen response

J Szymański, S Bocobza, S Panda, P Sonawane… - Nature Genetics, 2020 - nature.com
Wild tomato species represent a rich gene pool for numerous desirable traits lost during
domestication. Here, we exploited an introgression population representing wild desert …

Genetics and control of tomato fruit ripening and quality attributes

HJ Klee, JJ Giovannoni - Annual review of genetics, 2011 - annualreviews.org
Tomato ripening is a highly coordinated developmental process that coincides with seed
maturation. Regulated expression of thousands of genes controls fruit softening as well as …

Mass appeal: metabolite identification in mass spectrometry-focused untargeted metabolomics

WB Dunn, A Erban, RJM Weber, DJ Creek, M Brown… - Metabolomics, 2013 - Springer
Metabolomics has advanced significantly in the past 10 years with important developments
related to hardware, software and methodologies and an increasing complexity of …

Accumulation of flavonols over hydroxycinnamic acids favors oxidative damage protection under abiotic stress

V Martinez, TC Mestre, F Rubio… - Frontiers in plant …, 2016 - frontiersin.org
Efficient detoxification of reactive oxygen species (ROS) is thought to play a key role in
enhancing the tolerance of plants to abiotic stresses. Although multiple pathways, enzymes …

[HTML][HTML] Cranberries and their bioactive constituents in human health

JB Blumberg, TA Camesano, A Cassidy… - Advances in …, 2013 - Elsevier
Recent observational and clinical studies have raised interest in the potential health effects
of cranberry consumption, an association that appears to be due to the phytochemical …

Metabolic engineering of novel lignin in biomass crops

R Vanholme, K Morreel, C Darrah, P Oyarce… - New …, 2012 - Wiley Online Library
Lignin, a phenolic polymer in the secondary wall, is the major cause of lignocellulosic
biomass recalcitrance to efficient industrial processing. From an applications perspective, it …

Metabolomics for functional genomics, systems biology, and biotechnology

K Saito, F Matsuda - Annual review of plant biology, 2010 - annualreviews.org
Metabolomics now plays a significant role in fundamental plant biology and applied
biotechnology. Plants collectively produce a huge array of chemicals, far more than are …