Depression is currently among the top five leading causes of the global burden of disease.
Chronic unpredictable mild stress (CUMS) is currently the most commonly used, reliable …

Currently, over 300 million people worldwide have depression, and the socioeconomic
burden of this debilitating disorder is anticipated to increase markedly over the coming …

Anxiety disorders are complex diseases, and often co-occur with depression. It is as yet
unclear if a common neural circuit controls anxiety-related behaviors in both anxiety-alone …

Major depressive disorder affects around 16 per cent of the world population at some point
in their lives. Despite the availability of numerous monoaminergic-based antidepressants …

A single subanesthetic dose of ketamine, an NMDA receptor (NMDAR) antagonist, produces
rapid and sustained antidepressant actions in depressed patients, addressing a major …

Depression and type 2 diabetes (T2D) are highly comorbid disorders that carry a large
public health burden. However, there is a clear lack of knowledge of the neural pathological …

The valence of memories is malleable because of their intrinsic reconstructive property. This
property of memory has been used clinically to treat maladaptive behaviours. However, the …

Disrupted operations of the reward circuit underlie major emotional disorders, including
depression, which commonly arise following early life stress/adversity (ELA). However, how …

A markedly reduced interest or pleasure in activities previously considered pleasurable is a
main symptom in mood disorder and psychosis and is often present in other psychiatric …

Increasing evidence suggests a role for inflammation in neuropsychiatric conditions
including autism spectrum disorder (ASD), a neurodevelopmental syndrome with higher …