Pathological scars (PS) are involved in the excessive response of inflammation and
overactivation of myofibroblasts. Herein, a novel microneedle (MN) patch based on the …

Frostbite is the most common cold injury and is caused by both immediate cold-induced cell
death and the gradual development of localized inflammation and tissue ischemia. Delayed …

Collective alignment of cell populations is a commonly observed phenomena in biology. An
important example are aligning fibroblasts in healthy or scar tissue. In this work we derive …

Idiopathic pulmonary fibrosis (IPF) is characterized by persistent tissue injury, dysregulated
wound healing, and extracellular matrix (ECM) deposition by myofibroblasts (MFs) through …

The actin cytoskeleton plays a critical role in cell architecture and the control of fundamental
processes including cell division, migration and survival. The dynamics and organisation of …

Keloids are abnormal scars formed due to fibroblast dysfunction and excessively deposited
extracellular matrix (ECM). Despite the unclear process leading to the occurrence of keloids …

Keloids are a severe form of scarring for which the underlying mechanisms are poorly
understood, and treatment options are limited or inconsistent. Although biomechanical …

Desbuquois dysplasia type 2 (DBQD2) and spondylo-ocular syndrome (SOS) are autosomal
recessive disorders affecting the extracellular matrix (ECM) and categorized as …

Many biological structures take the form of fibres and filaments, and quantitative analysis of
fibre organisation is important for understanding their functions in both normal physiological …

In this work we analytically investigate the alignment mechanism of self-propelled ellipse-
shaped cells in two spatial dimensions interacting via overlap avoidance. By considering a …