Lipoic acid is an essential cofactor for mitochondrial metabolism and is synthesized de novo
using intermediates from mitochondrial fatty-acid synthesis type II, S-adenosylmethionine …

Intracellular reduction–oxidation (redox) homeostasis, mediated mainly by reactive oxygen
species (ROS), plays a significant role in physiological function maintenance and regulation …

Reactive oxygen species (ROS) affect many cellular functions and the proper redox balance
between ROS and antioxidants contributes substantially to the physiological welfare of the …

Hydrogen/Deuterium eXchange Mass Spectrometry (HDX-MS) is a rapidly evolving
technique for analyzing structural features and dynamic properties of proteins. It may stand …

Abstract The Pentose Phosphate Pathway (PPP), a metabolic offshoot of the glycolytic
pathway, provides protective metabolites and molecules essential for cell redox balance and …

Proteasome inhibitors (PIs), such as bortezomib and calfizomib, were backbone agents in
the treatment of multiple myeloma (MM). In this study, we investigated bortezomib interactors …

Background The human mitochondrial alpha-ketoglutarate dehydrogenase complex
(hKGDHc) converts KG to succinyl-CoA and NADH. Malfunction of and reactive oxygen …

α-ketoglutarate dehydrogenase complex (KGDHc), or 2-oxoglutarate dehydrogenase
complex (OGDHc) is a rate-limiting enzyme in the tricarboxylic acid cycle, that has been …

The failing heart is characterized by an increase in glucose uptake and glycolytic rates that
is not accompanied by a concomitant increase in glucose oxidation. Lower coupling of …

Are the symptoms of autism caused by a treatable metabolic syndrome that traces to the
abnormal persistence of a normal, alternative functional state of mitochondria? A small …