Abstract Our previous International Union of Basic and Clinical Pharmacology report on the
nomenclature and classification of adenosine receptors (2011) contained a number of …

Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …

Neural network (NN)-based protein modeling methods have improved significantly in recent
years. Although the overall accuracy of the two non-homology-based modeling methods …

The adenosine A2A receptor (A2AR) is a prototypical G protein-coupled receptor (GPCR)
that couples to the heterotrimeric G protein GS. Here, we determine the structure by electron …

Signaling across cellular membranes, the 826 human G protein-coupled receptors (GPCRs)
govern a wide range of vital physiological processes, making GPCRs prominent drug …

G-protein-coupled receptors (GPCRs) are the largest class of signaling receptors that are
most frequently targeted by therapeutic drugs. Allosteric modulators bound to GPCRs at …

Adenosine is an endogenous purine-based nucleoside expressed nearly in all body tissues.
It regulates various body functions by activating four G-protein coupled receptors, A 1, A 2A …

The human proteome contains 826 G protein-coupled receptors (GPCR), which control a
wide array of key physiological functions, making them important drug targets. GPCR …

A long evolution of knowledge of the psychostimulant caffeine led in the 1960s to another
purine natural product, adenosine and its A2A receptor. Adenosine is a short‐lived …

Currently, the most promising therapeutic modality for cancer treatment is the blockade of
immune checkpoint pathways, which has revolutionized cancer therapy in the past 15 years …