The changes that occur in the regional circu-lations with congestive heart failure depend on
a number of variables:(A) the stimulus for heart failure;(B) the severity of heart disease;(C) …

Nitroglycerin (NTG) and isosorbide dinitrate (ISDN) are potent dilators of vascular smooth
muscle. The organic nitrates produce venodilation at very low doses, with little additional …

Background—Recent studies suggest that amlodipine may reduce mortality in patients with
heart failure, especially those with dilated cardiomyopathy. In general, drugs that release …

Vasodilatory responses of segments of large epicardial left coronary artery (CA), small
intramyocardial CAs (0.3-1.0 mm), coronary stenoses and CAs filled by collaterals were …

Nicorandil, a nicotinamide derivative, is an orally efficacious antianginal drug possessing a
nitrate moiety in its chemical structure. This drug is an effective and welltolerated treatment …

The results of a study to characterize the effects of the oral administration of isosorbide-5-
mononitrate (Is-5-Mn), the active metabolite of isosorbide dinitrate, on portal hypertension in …

Digitalis and diuretics constitute conventional therapy of congestive heart failure, but
systemic vasodilators offer an innovative approach in acute and chronic heart failure of …

This study investigated whether oral doses of isosorbide–5–mononitrate, a preferential
venous dilator that decreases portal pressure, could enhance the effects of propranolol on …

A rapid increase in isoflurane or desflurane concentration induces tachycardia and
hypertension and increases plasma catecholamine concentration. Little information is …

Coronary artery reocclusion after thrombolysis with human recombinant tissue-type
plasminogen activator (rt-PA) is related to the short half-life of this agent in plasma. K2P, a …