For almost a century, vitamin A has been known as a nutrient critical for normal
development, differentiation, and homeostasis; accordingly, there has been much interest in …

Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

The key role of vitamin A in embryonal development is reviewed. Special emphasis is given
to the physiological action of retinoids, as evident from the retinoid ligand knockout models …

The pleiotropic effects of retinoids are mediated by nuclear retinoid receptors (RARs and
RXRs) which are ligand-activated transcription factors. In response to retinoid binding …

Vitamin A is essential for the formation and maintenance of many body tissues. It is also
important for embryonic growth and development and can act as a teratogen at critical …

We have identified and characterized a new orphan member of the nuclear hormone
receptor superfamily, called MB67, which is predominantly expressed in liver. MB67 binds …

NUCLEAR receptors regulate the transcription of complex networks of genes and thereby
control diverse aspects of growth, development, and homeostasis. The nuclear receptor …

Complexity in the retinoid signalling system arises from a combination of several forms of
retinoic acid, multiple cytoplasmic binding proteins and nuclear receptors, and the existence …

We have purified and cloned a HeLa cell nuclear protein that strongly stimulates binding of
retinoic acid and thyroid hormone receptors (RARs and TRs) to response elements. The …

We investigated the clinical, histologic, and molecular responses of normal human skin to all-
trans-retinol (ROL) application, compared to those induced by topical all-trans-retinoic acid …