DNA-encoded chemical libraries (DELs) represent a versatile and powerful technology
platform for the discovery of small-molecule ligands to protein targets of biological and …

Click chemistry, proposed nearly 20 years ago, promised access to novel chemical space by
empowering combinatorial library synthesis with a “few good reactions”. These click …

Over the past decade, DNA-encoded libraries (DELs) have emerged as a leading platform
for small molecule drug discovery among pharmaceutical companies, biotech companies …

Encoding small-molecule information in DNA has been leveraged to accelerate the
discovery of ligands for therapeutic targets such as proteins. However, oligonucleotide …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed more than 4
million humans globally, but there is no bona fide Food and Drug Administration–approved …

A DNA-encoded library is a collection of small molecules covalently linked to DNA that has
unique information about the identity and the structure of each library member. A DNA …

The world is totally dependent on medications. As science progresses, new, better, and
cheaper drugs are needed more than ever. The pharmaceutical industry has been …

Bromodomain testis (BRDT), a member of the bromodomain and extraterminal (BET)
subfamily that includes the cancer targets BRD2, BRD3, and BRD4, is a validated …

Triazoles are privileged structural motifs that are embedded in a number of molecules with
interesting biological activities. In this work, we developed a practical and general synthetic …

Mass-spectrometry-based chemoproteomics has enabled the rapid and proteome-wide
discovery of functional and potentially'druggable'hotspots in proteins. While numerous …